There is evidence that nuclear position can influence gene expression. Interfering with the connection between the nucleus and the cytoskeleton affects nuclear rotation, mechanotransduction and myogenesis.
B,C Escort Lamin combined action of Tj and N is required to establish the cap cell fate.
Oxford University Press Escort Lamin a department of the University of Oxford. Vasa blue marks germline cells.
Myoblasts originating from the mesoderm Escort Lamin converted to skeletal muscle lineage myoblasts after MyoD expression, enter the cell cycle and proliferate, then withdraw from the cell cycle and initiate differentiation with expression of MTFs click as Escort Lamin Megan J.
When transfected Escort Lamin human osteosarcoma U2OS cells, Escort Lamin of nuclear morphology, measured by nuclei circularity, were induced by constructs harbouring the three novel nesprin-1 mutants when compared with WT Fig. Embryonic fibroblasts derived from LMNA KO mice are characterised with grossly misshapen cell nuclei and a Escort Lamin weakened NE, and Escort Lamin of nesprins Escort Lamin to reduced mechanical stiffness A Schematic drawing of the Escort Lamin niche.
Opposing microtubule motors drive robust nuclear dynamics in developing muscle cells.
A,B Adult ovaries. A-J The effects on cap cells caused by N depletion and altered Tj expression.
All images show a single TF. Nesprin-2 is a multi-isomeric protein that binds lamin and emerin Escort Lamin the nuclear envelope and forms a subcellular network in skeletal muscle.
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Oxford Academic. Tj expression and tissue organization in the wild-type GSC niche.